Hi Nithya Velusamy
I have attached paper regarding the same.
Also when you do this reaction you have to make sure Cuprous oxide is freshly prepared and reaction should also be done in inert atmosphere.
DMSO used should be distilled and can be degassed before reaction.
NaN3 with L-proline in presence of cuprous oxide in DMSO as a solvent should work. Nithya Velusamy
Hello Nithya,
many thanks for posting this very interesting technical question on RG. In addition to the relevant references which have already been suggested, please also have a look at the following potentially useful article which might help you in your analysis. The paper reports a rather quick and straightforward synthesis of a variety of aryl azides from the corresponding aryl bromides:
Rapid Synthesis of Aryl Azides from Aryl Halides under Mild Conditions
Article Rapid Synthesis of Aryl Azides from Aryl Halides under Mild Conditions
Unfortunately this article has not been posted as public full text on RG. However, three of the authors have RG profiles. Thus there is a good chance that you can request the full text directly from one of the authors via RG.
Also please check the answers given to the following closely related question which has been asked earlier on RG. It might be helpful:
How can we get aryl-azide from aryl-bromide?
https://www.researchgate.net/post/How-can-we-get-aryl-azide-from-aryl-bromide
(10 answers)
Good luck with your research and best wishes, Frank Edelmann
You can convert Aryl Bromide to Aryl Azides by treating aryl bromides with sodium azide in a polar solvent.
In case of an aryl bromide which is liquid at R.T. or low-melting I would try solid sodium azide with the addition of a very small quantity of DMF as solubility "catalyst". You should expect liquid aryl azide and solid NaCl which you can separate by filtration.
A very good compilation is given in the book: Organic Azides, Syntheses and Applications, Stefan Bräse, Klaus Banert, ISBN 978-0-470-51998-1.
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