hello, I want to know, how can I confirmed the contamination of the ion source in GCMSD Agilent technology
Look at the analytes of interest in a BLANK sample, I don't understand? Blank samples won't confirm that the ion source is dirty. Look at mass 502 after tuning if it's to low then your ion source could be dirty. Also look at the history of the EM voltage of the last couple of tunes, if it's rising quickly your ion source could be dirty.
If you spent more than a few hours to investigate if you ion source is dirty than it's easier and faster to just vent the MS, take the ion source out and if it's dirty clean it. You should be up and running again in 3-4 hours hours.
If you regularly analyze dirty samples you should clean the ion source every 2-4 months. With clean samples maybe once a year or less.
The best way would be that you inject a blank sample and monitor the response of the MS. You should not get a reasonable response for the analytes of interest, but only noise or flat baseline. If it happen that you do receive an indication of the presence of analyst, it confirms the contamination.
Look at the analytes of interest in a BLANK sample, I don't understand? Blank samples won't confirm that the ion source is dirty. Look at mass 502 after tuning if it's to low then your ion source could be dirty. Also look at the history of the EM voltage of the last couple of tunes, if it's rising quickly your ion source could be dirty.
If you spent more than a few hours to investigate if you ion source is dirty than it's easier and faster to just vent the MS, take the ion source out and if it's dirty clean it. You should be up and running again in 3-4 hours hours.
If you regularly analyze dirty samples you should clean the ion source every 2-4 months. With clean samples maybe once a year or less.
I agree Alex. The simplest solution is just to clean the source and try again.
if the tune does not work or giving bad results you probably have a contaminated ion source. If you have constant mass background it is nearly newer the ion source as compounds are usually evaporated and pumped away in the system. constant backgrounds usually comes from the GC.
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