I have a phenotypic trait I am interested in, and a number of SNPs have been reported in literature to be associated with the trait (GWAS studies).

Each SNP is associated with the trait with its own estimated effect and p-value. I would like to combine them in an overall index, so that based on the genotypes of a new subject at those SNP loci, I could come up with a genetic value/score for that individual for the trait.

The first step could simply be to add the estimated SNP effects, but in this way I would not take into account the different significance with which the SNPs are associated with the trait. Alternatively, I could weigh the SNP effects by their p-value (or inverse of).

Any other ideas? Examples from literature?

Thanks!

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