THESE ARE SIMPLE EXCEL  CALCULATIONS REFER FOLLOWING WHICH MIGHT HELPFUL FOR YOU                                                                                       C              .                  

simple hplc quantification will give result

Thanks both of you

My suggestion is to use the Weibull equation. The equation allows you to determine the mean dissolution time that is a robust parameter fro comparing the different results. Waybill equation is used also for comparing the dissolution of generic products in comparison with the originator.

Amount of drug released (calculated from calibration curve)

___________________________________________________ * 100

Theoretical amount

I agree with Chella. Basic equation is right.  Amount released should be cumulative amount released in total amount of the medium used. Cumulative calculation has to be correctly taken.

If the problem is simply to calculate the % released, what you need is to know the amount of drug contained in the dosage form. You have to make an assay of samples of the batch and than estimated the drug content of the form under test from its weight.

First, You have to find out dissolution method and analytical method for the drug. and for calculation you can use the attached file.

Regards

Dear Ashraf Islam 

which equation did you follow?

Dear Ashraf,

1) You need to have a suitable analytical technique (UV spectrophotometry or HPLC) and standard plot of your drug  in the dissolution medium you are using for the release studies.

2) During  dissolution studies you will be withdrawing various aliquots and analyzing the drug content in them by your method.

3) From calibration/std plot find out amount in the withdrawn aliquots.

4) By simple mathematics you can calculate the amount in total dissolution medium  (900ml). From 2nd reading onwards, you need to add the cumulative amounts released in the withdrawn volumes.

5) Then you can compute 5 released at each time point based on total drug (label claim) in your solid oral dosage form.

can anyone give me the equation to determine initial rate of dissolution??

amount of drug = Conc × Volm of medium ×dilution factor / 1000(correction factor)

% drug release = amount of drug / theoretical drug amount × 100

Can you please clarify what is the theoretical drug amount? is it the total amount that is loaded in the dialysis bag?

Mala Menon Madam has explained well

Can anyone send me the excel sheet to calculate drug release? I have doubt in calculation, pls help me

How to adjust drug dissolved in case of multiple sample analysis, as in modified release products?

Use password (16440) to open the excel file.

This is a simple excel software (PCP disso xls.) to calculate % drug release, just put the value of absorbance, slope & intercept value from the calibration curve , vol of dissolution media (mL), sampling point, amount of drug (mg) to get the results. you can also calculate flux for skin permeability and kinetics of drug release (Model fitting).

Hope this will help you.

Put the absorbance data of the samples (collected at predetermined time) into the standard curve of the drug. Then divide the obtained value to total amount of the drug encapsulated in the NPs and multiply with 100, you will obtain cumulative drug release at that time interval. (Copied)