I am performing a cell viability assay in which I am combining a costant fix amount of drug A (at its IC25) and increasing concentration of drug B. For both the single drugs I have the IC50s but as you can imagine I do not have a costant ratio between the two drugs in my titration.
Is there a way to calculate the CI and define any synergistic or additive effect? Can you suggest any software that does it?
Dear Sara
can you change the design of your study for A and B.
That gradually you increase concntration A and same time you decrease the concentration B.
(10% A and 90% of B, 20% A and 80% B............50%A and 50% B.....90%A and 10%B).
Hi Sharad,
I have already performed the combo but I can reset the assay for the most interesting combinations as you proposed.
In any case do you have any suggestion about software analysis?
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