To study new features in proteases and peptidases that might make them work better, we can use several bioinformatics methods. First, we look at their sequences to find patterns or regions that are similar to known enzymes using tools like Pfam or InterPro. If there are new regions, we compare them across multiple sequences to find important parts. Next, we predict their 3D shapes using tools like AlphaFold to see how they might work. We can also compare them to similar enzymes to spot differences. Finally, by studying their evolution and using computer models, we can predict which features make them special and test these ideas in experiments.