I did a two-level full factorial design in order to find the significance of three factors (A, B, C) and their interactions on a response (R). Due to interaction between minimum level of A and maximum level of C at two runs, a situation turned up that R is not detectable. How can I treat with such a case? Shall I put these two runs away and analyze the remained ones? If so, what should I do with this non-orthogonal condition?