If synthesized the material in DMSO. My product is water labile makes strong emulsion with water. How can I remove DMSO from the product?
I guess, if your product is not soluble in ether. Then mix your material with excess ether and use separating funnel
You can do dialysis. If you dialyze your sample against pure water, you can get rid of DMSO and end up having an aqueous solution.
If rotavapor at 50 to 60 C under high vacuum (good oil pump) is not working! and if your compound dissolves better (loves more) in cyclohexane, heptane, hexane, pentane, 2,2,4-trimethylpentane or diethyl ether (all these not miscible with DMSO) you can extract your product in one of these solvents with a separating funnel and then more easily remove with rotavapor the more volatile solvent (i. e. pentane and diethyl ether evaporate under atmospheric pressure at 40-60 C).
Try with just solvents the rotavapor before you place your samples under vacuum.
My compound is highly polar. so cant use extraction with non polar solvents.
Seems DMSO was a bad choice. The only thing which comes to mind is look for a DMSO miscible nonsolvent (preferably volatile) to precipitate the product. Wash the precipitate with the nonsolvent and dry.
donot know whether the problem was solved or not however lowering the temp to 10 0C wil freeze DMSO but not water you can filter the aqueous solution containing water soluble compound and separate DMSO as solid
would be surprised if DMSO in mixture with water freeze at 10°C. There is strong interaction with water.
Thanks to all I think, tracing a non solvent for DMSo is good choice if possible.
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