By what measure we can induce cerebral blood flow which can be correlated with wide range of arterial stiffness?
Yogesh Kumar
Aortic stiffness can affect cerebral blood flow through several mechanisms: Pulsatility: Increased aortic stiffness leads to a higher magnitude of pressure pulsations, resulting in increased pulsatility in the cerebral arteries. This may contribute to fluctuations in cerebral blood flow, potentially affecting the regulation of cerebral perfusion. Pressure Wave Reflections: Stiffness can cause earlier and stronger wave reflections from the periphery back to the heart. These reflected waves can interact with forward-moving waves, potentially leading to elevated systolic and decreased diastolic blood pressure in the brain's microvasculature, which may have implications for cerebral perfusion. Impaired Autoregulation: Aortic stiffness can impact cerebral autoregulation, the brain's ability to maintain relatively constant blood flow over a range of systemic blood pressures. Altered autoregulation due to aortic stiffness could lead to reduced flexibility in adapting to changes in blood pressure. Neurovascular Coupling: Neurons consume oxygen when they are active. Increased neural activity leads to increased local oxygen consumption. In response to increased neural activity, the brain's blood vessels dilate (vasodilation) to deliver more oxygenated blood to the active region. This is known as the neurovascular coupling response. fNIRS Measurement:fNIRS employs near-infrared light to measure changes in the concentrations of oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (HbR) in the cortical tissue. When neurons are active, oxygen consumption increases, leading to a decrease in local oxygen levels and an increase in deoxygenated hemoglobin. fNIRS detects these changes in hemoglobin concentrations by measuring the differential absorption of near-infrared light. Analyzing Cerebral Blood Flow Changes: By monitoring changes in HbO2 and HbR, fNIRS indirectly captures the changes in cerebral blood flow associated with neural activity. You can use fNIRS to create hemodynamic response curves that illustrate how changes in neural activity are linked to changes in oxygenation and blood flow in the brain.
fNIRS can be used to measure changes in cerebral blood flow by following method:-
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Kumar Siddharth
Changes in aortic stiffness could affect cerebral blood flow. The following paper may be a good read to build some perspective.
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