https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext
During a cytokine storm, an excessive immune response ravages healthy lung tissue, leading to acute respiratory distress and multi-organ failure. Untreated, cytokine storm syndrome is usually fatal. Patients in other studies who developed cytokine storm syndrome after viral triggers often ironically possessed subtle genetic immune defects resulting in the uncontrolled immune response.
Once diagnosed , it’s best to overcome “Cytokines Storm” as quickly as possible with efficacious and appropriate drugs...
Best suited “Immunomodulators” are to be used because nowadays “Host directed therapies” are much preferred in such immune responses.....
Cytokin storm that started in lungs then multiorgan failure mimicking HLH and Cytokin releasing syndrome post chemotherapy.. Needs to deal with similar first line protocol of HLH 2004.. Dexamethason Vp16. And follow patient conditions.
SARS-CoV-2 infection complicated by inflammatory syndrome. Could high-dose human immunoglobulin for intravenous use (IVIG) be beneficial?
Prete M, Favoino E, Catacchio G, Racanelli V, Perosa F.
Autoimmun Rev. 2020 Apr 30:102559. doi: 10.1016/j.autrev.2020.102559. [Epub ahead of print] No
Best therapies for COVID-19 induced immune storm are:
1. Steroids - Dexamethasone is the best
2. IL-6 inhibitors: e.g Tocilizumab and interferon-alpha
3. COVID-19 convalescent plasma pre-checked for adequate SARS-CoV-2 antibodies after blood group matching.
1. Preprint Effect of Dexamethasone in Hospitalized Patients with COVID-...
2. What is the role of interleukin (IL) inhibitors in the treatment of coronavirus disease 2019 (COVID-19)?
https://www.medscape.com/answers/2500114-197455/what-is-the-role-of-interleukin-il-inhibitors-in-the-treatment-of-coronavirus-disease-2019-covid-19
3. Preprint Convalescent Plasma Therapy for Covid-19: State of the Art
Better to prevent with human immunoglobulin for intravenous use (IVIG)
