We are currently isolating new thiourea derivatives with palmitoyl side chains. We are making little progress in obtaining crystals suitable for x-ray studies. We have obtained for only one compound out of about 7 compounds.
We never worked with these particular compounds. However, with such long-chain aliphatic substituents I assume that your thiourea derivatives might even be soluble in aliphatic hydrocarbons. I suggest to try a higher-boiling aliphatic hydrocarbon such as n-heptane. You could then try to dissolve your samples in boiling n-heptane and then slowly cool the solutions to room temperature. In order to achieve a very slow cooling and perhaps get nice crystals you could place the hot solutions in a Dewar vessel filled with hot water and let them slowly cool down over night. If aliphatic hydrocarbon solvents don't work, you could try the same procedure with toluene. In very different cases we also had excellent results when using acetonitrile for recrystallization. Good luck!
Dear Asegbeloyin Jonnie Niyi have you been able to get suitable single-crystals in the meantime?
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