It is noted that AZD8055 is a potent, selective ATP-competitive inhibitor of target of rapamycin (TOR). How azd8055 ihibit mTOR activity? What is the mechanism? any illustrated explanation available?
mTOR is a serinine/threonine kinase, which means it attaches a phosphate to the hydroxyl of serinine or threonine in target proteins, which tends to activate or inactivate those target proteins. The kinase reaction requires ATP - that's where mTOR gets the phosphate group from. ATP is converted to ADP as a result.
AZD8055 is ATP competitive - it occupies the ATP binding site, so that ATP cannot get in. Without ATP, mTOR does not have access to a phosphate group. Without that phosphate group, mTOR can't phosphorylate serine or threonine.
AZD8055 works by preventing mTOR's access to the reagents it needs to catalyze a kinase reaction.
Thank you very much Dr. William make this more clear to understand. Does not this affect to other Kinase reactions in the cell? if ATP is limiting how does cell survive?
The above explanation is very good and detailed and that is how exactly what is known until now, how it competes for the ATP and thereby inhibits an active mTOR kinase.
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