When a drug is size reduced, it develops static charge on them. What exactly is the mechanism involved in this?
This is difficult to answer without more details. Charges on particles are the result of interactions between the surrounding medium and the surface of the particle. For example a pH change may alter the effective charge of the particle due to the behavior of surface bound groups. Adding surfactants that get absorbed or desorbed may also influence the effective charge. Even non-ionic components can alter the surface (and thus effective charge) characteristics via a mechanism called steric stabilization. Not sure if the link below can help, except to state that the interface between the particle and the surrounding medium is more relevant than the size of the particle.
http://www.materials-talks.com/blog/2015/01/06/surface-zeta-potential-what-it-is-and-how-to-measure-it/
This question could also relate to dry milling of a milling where electrostatic (tribological) charge can be added by removal of electrons in the same manner that rubbing a balloon and sticking it to a cat or picking up paper with a rubbed amber wand - i.e. friction... Most of the energy in comminution (size-reduction) processes is not used in reducing particle size but is used to generate, heat, sound, and sometimes light. See for example:32. August 3rd 2010 Comminution - history and laws https://www.brainshark.com/malvern/vu?pi=zF1zHVj17z5chz0&tx=preview
https://www.brainshark.com/malvern/vu?pi=242583221&text=M021507
I was also wondering when the size increase, will the zeta potential decrease?
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology
- Pharmaceuticals
- Drugs