Hello, Christa! When I did the same search I found the most of research with HFD or HCD but the combinations in form of HFHCD are not commonly used by researches. Maybe this papers will help you in your searching

Buettner, R., Schölmerich, J., Bollheimer, L.C., 2007. High-fat Diets: Modeling the Metabolic Disorders of Human Obesity in Rodents*. Obesity 15, 798–808. doi:10.1038/oby.2007.608

Hariri, N., Thibault, L., 2010. High-fat diet-induced obesity in animal models. Nutr. Res. Rev. 23, 270–299. doi:10.1017/S0954422410000168

Hebbard, L., George, J., 2011. Animal models of nonalcoholic fatty liver disease. Nat. Rev. Gastroenterol. Hepatol. 8, 35–44. doi:10.1038/nrgastro.2010.191

Gadja, A.M., 2008. High fat diets for diet-induced obesity models. Res. Diets 2008–2010.

We used HFHCD to design NAFLD (and HFD without NAFLD in young rats also)

Article Evaluation of tissue metal and trace element content in a ra...

Article Early High-Fat Feeding Induces Alteration of Trace Element C...

Hello, Christa!

I have always used only high-fat diet, according to experimental models from previous studies. Other researchers at the university use high-sugar, using sucrose. But usually we use one or the other, not both.

Hi Christa,

It seems to depend a lot on the strain of animal, I would suggest high fat though the carbohydrate source may also be important. I recently came across this paper though which i found to be good:

Kazusa Sato,

Hidekazu Arai,

Akira Mizuno,

Makiko Fukaya,

Tadatoshi Sato,

Megumi Koganei,

Hajime Sasaki,

Hironori Yamamoto,

Yutaka Taketani,

Toshio Doi,

and Eiji Takeda

Dietary Palatinose and Oleic Acid Ameliorate Disorders of Glucose and Lipid Metabolism in Zucker Fatty Rats J. Nutr. August 2007 137: 8 1908-1915

The group has also published other papers using the same diet.

Hi Christa,

We are using High-carbohydrate High-fat diet to induce obesity and obesity associated metabolic parameters. The detail reasons are given in provided article.

Panchal SK, Poudyal H, Iyer A, Nazer R, Alam A, Diwan V, Kauter K, Sernia C, Campbell F, Ward L, Gobe G. High-carbohydrate high-fat diet–induced metabolic syndrome and cardiovascular remodeling in rats. Journal of cardiovascular pharmacology. 2011 Jan 1;57(1):51-64.

In comparison with other models of diabetes and obesity, this diet-induced model more closely mimics the changes observed in human obesity associated metabolic syndrome.

Hi Christa,

It may be a bit too late, but I would like to chip in my opinion here. I think most research groups would use whichever diet that is effective in inducing obesity. Therefore, the choice of obesity-inducing diet will depend on what the group has previously established, others' published studies and in-house pilot studies. I agree with Shaan that the animal strain can have a great influence on the efficacy of disease induction. If you go through some review papers like [1], [2] and [3], you may also find that there is no clear indication about which diets (HFD or HFHS) is superior, although it is presumed that HFHS resembles more closely to unhealthy human dietary pattern. Yet, the fact is there is very limited studies that make direct comparisons between different types of diets/animal strains/starting age in terms of their disease induction efficiency. Therefore, it is very hard to make an informed decision about which diets is superior.

As for your second question, based on my personal experience, I would say both HFD and HFHS are not effective in inducing hyperphagia even though such an effect has been reported before. Well, the reason is probably quite simple. Imagine you are provided your favorite food day after day for all three meals, would you still like it very much after two week? What about after 6 months? This is because the animals had to feed on the same diet for that long (or even longer) in certain studies. Of course, it may be argued that the animal behavior could be different from human behavior, in which case I am incapable to comment further because it is not my expertise.

If you are interested in hyperphagia-inducing diets, cafeteria diet may suit you. You may refer to [4] and [5]. Briefly, instead of providing a single, formulated diet, cafeteria diet provides different (unhealthy) food choices to the animals. It seems to induce hyperphagia more reliably. There are other genetic models like ob/ob and db/db mice and Zucker fatty rats which are naturally hyperphagic due to leptin or leptin receptor mutation.

I hope this helps.

Review articles

[1] Article Animal models of metabolic syndrome: a review

[2] https://www.hindawi.com/journals/bmri/2011/351982/

[3] Article Today's and yesterday's of pathophysiology: Biochemistry of ...

Cafeteria diet

[4] Article Cafeteria Diet Is a Robust Model of Human Metabolic Syndrome...

[5] https://www.nature.com/articles/ijo2017225

I recommend you this articles, that compared 3 different diets: Article A new animal diet based on human Western diet is a robust di...

Hi,

always used only high-fat diet, or high- proten or high -fiber ,according to experimental models from previous studies. But usually we use one or the other.