Hi everybody, Where could I find a step-by-step user manual for Waters LCMS Xevo G2 xs? Thank you very much.

More Ilian Simidjiev's questions See All

How in practice to receive entangled photons?

I would be very thankful if somebody helps me with some practical advices about producing twin photons? I know that twins are produced after a laser ray is directed on a BBO crystal. After the BBO...

14 May 2024 9,208 2 View

How has the Feynman paths integral for entangled photons be constructed?

In path integral formulation of QM Feynman show that for a photon every possible path should be taken. I'm puzzled how this must be applied for entangled photons. Let there is a pair starting at...

05 May 2024 7,461 7 View

Can a hollow tube be an ideal superconductor?

If we make a hollow tube and create vacuum inside, than apply negative voltage on the wall - what will be the movement of electrons inside when we apply voltage at the ends of this tube? Is it not...

12 November 2021 5,006 10 View

Is there a method like the described below in virology?

My specialty is quantum physics but because of the pandemium I was interested in physical methods applied to virology. Today's physics is at nanolevel manufacturing so I suppose it can solve...

26 April 2020 2,771 1 View

What does it mean for two photons to be path entangled?

I understand what is two photos to be entangled in polarization. Or two electrons in spin. What are the basics of path entanglement? Are the photons SPDC 0 and I path entangled? What happens two...

07 January 2019 4,183 0 View

QM, Feynmann and partial reflection?

In the Feymann QED strange theory of light he describes the partial reflection. There he mention that Newton made an experiment which poined for intereference of 34 000 wavelenghts thick...

29 April 2017 6,001 25 View

Is this Intrepretation of the wave function possible?

I would like to put to the critic of the RG participants a hypothesis about the nature of the wave function (WF) - more specifically about WF collapse. According to it: the particle is a real...

19 June 2016 7,609 9 View

Is this an example of something from nothing?

When an electron passes thru a magnet (like in the Stern-Gerlach experiment) the projection of its spin changes. The biggest change is when the projection is perpendicular to the magnetic field....

02 May 2016 6,764 25 View

Does the energy of the photon change in Beth 1936 experiment?

When a left (right) polarized photon reflects from a birefringent plate it changes its polarization to right (left). The internal orbital momentum of the photon thus changes by 2hbar. The orbital...

29 March 2016 4,497 8 View

Is there any way to split a linear polarised photon into left and right polarised photons?

Dirac pointed out that a linear polarized photon is a superposition of right and left polarized photons. Is there an experimental way to split them?

28 January 2016 9,318 20 View

How can major oxides determined by ICP-MS/ES be normalized to 100% volatile free? How does this connect with LOI?

I am analyzing cherts from different sources found within one specific geologic formation using ICP-MS/ES. My committee was asking this question about my analysis. I was not sure how to answer this

05 August 2024 7,902 3 View

Usage of internal standards in LC-MS/MS analysis?

Have you ever seen a LC-MS/MS method uses both internal standards and external standards (in matrix matching purpose) but the concentrations of internal standards are outside the calibration curve...

05 August 2024 3,083 6 View

AGILENT HPLC 1100 SERIES , any expert available please?

AGILENT HPLC 1100 SERIES operation assistance needed.

25 July 2024 10,045 2 View

How to select relevant metabolites from multiple annotations ?

I am using the Polyomics Integrated Metabolomics Pipeline (PiMP) for metabolite feature analysis. After annotating my data, I have encountered cases where multiple potential metabolites are...

24 July 2024 5,789 0 View

MS/MS spectrum with 5 Da difference in m/z value?

Hi everyone, We experienced a strange pattern in some spectra coming from HRMS/MS analysis. In particular, in the MS1 spectrum a base peak at m/z=M and a smaller peak at m/z=M+5Da appear, but in...

08 July 2024 3,631 4 View

Increasing Area Ratio on Quality control Standard on LCMS ?

Hello everyone. During my analyses on LC MSMS, the area ratio (Standard Area/Isotopically labelled Standard Area) increases with time for the quality control point. I'm having trouble explaining...

08 July 2024 3,150 2 View

Can anybody explain the term "Peak- Rating" in data obtained from LC/MS?

Data Acquisition detected more than 65000 metabolites with area maximum, RT-value and peak-rating. What is the significance of Peak Rating?

07 July 2024 6,643 2 View

My cells need to be treated 4 times (0-72hrs) and then take conditioned media for LC-MS. Can I keep them in serum free for so long? Recommendations?

I have tried to optimize the serum free dmem which is the best but i am afraid the secretory profile has too much variations.

03 July 2024 4,044 3 View

On what basis you choose Mass spec %Cov(95) cutoff score to validate a protein through CoIP?

I am working on centrosomal proteins. I overexpressed my POI and then I did SNAP capture pulldown followed by mass spec and I got approximately 700 protein hits. I am trying to validate specific...

03 July 2024 5,701 0 View

What is meant by Hits (DB) in High-Resolution Liquid Chromatography-Mass spectrometry (HR-LCMS) analysis compound table report?

In the qualitative compound report obtained from HR-LCMS analysis of crude plant extracts, what is meant by Hits (DB)? Should we consider all the predicted compounds from the list for further studies?

30 June 2024 2,290 4 View

William Letter

The "manuals" are terrible. Strongly recommend that you hire someone to come in and provide practical and professional training to you. You will learn MUCH faster that way. Waters also can provide training classes too, but the best way to learn a new or existing system is to have a pro on-site, using your instrument, provide hands-on training.

Ilian Simidjiev

Thank you very much. We just had a training session. More or less it works.