It is not possible to dissolve the chitosan in DMSO with out dilute acid. You should use water soluble chitosan for this purpose.
As told by Mr. K.A. Martin Xavier, Chitosan can not be dissolved without adding acid. I have heard about the water soluble Chitosan which is prepared by hydrolysing Chitosan using hydrogen peroxide.
Acetic acid can alone dissolve Chitosan. I have prepared gel of Chitosan by using 1% acetic acid solution and from that I have made Chitosan beads for my adsorption experiments.
Hi Maliha,
As already told by others. It is difficult to dissolve chitosan in DMSO.
However, regarding to this paper https://www.researchgate.net/publication/244728743_Dissolution_of_Chitosan_in_Dimethyl_Sulfoxide_by_Salt_Formation, some of chitosan salts, such as salicylic acid, can dissolve in DMSO.
Here is protocol from that paper:
Chitosan (NHAc = 0.2, Mn = 24000) dissolved in water in the presence of equimolar of acid listed in Table 1. After freeze drying of aq chitosan salt solution, a part of chitosan-acid salts such as pTsOH, CSA, MeSO3H, and salicylic acid (2-HOC6H4COOH) dissolve in DMSO.
Article Dissolution of Chitosan in Dimethyl Sulfoxide by Salt Formation
I have made chitosan aspirin adduct. Can anyone please guide me in which solvent it would be soluble?
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