I am an M.Pharm student, currently pursuing a research project. I am trying to make Hesperidin-chitosan nanoparticles, but, it was failed attempt as Hesperidin is getting precipitated in the acidic environment and chitosan is soluble only in an acidic environment (I used 1% acetic acid).

So, I added HPBCD to tackle this problem, and now hesperidin is not precipitating. However, the entrapment efficiency of nanoparticles prepared this way is too less (almost 16%) And the Zeta potential is too large (almost 34).

Can anyone please suggest what can be the next to right approach? Any suggestion would be of great help.

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