Herpes simplex virus (HSV) is an ubiquitous, enveloped, and doublestranded DNA virus, belonging to the family of Herpesviridae transmitted across mucosal membranes and nonintact skin, that migrate to nerve tissues, where they persist in a latent state. HSV-1 predominates in orofacial lesions, and it is typically found in the trigeminal ganglia, whereas HSV-2 is most commonly found in the lumbosacral ganglia [1]. Nevertheless these viruses can infect both orofacial areas and the genital tract.