What are hemizygous and nullizygous?
How they present on chromosome and what are their effect?
Nullizygous refers to an organism carrying two loss-of function alleles for the same gene. For example, two independent loss of function mutations which are different but both result in los of function. This is different from homozygous in which the two mutations that cause loss of function are identical.
Hamizygous? That one I don't know. Correct spelling?
Nullizygous refers to an organism carrying two loss-of function alleles for the same gene. For example, two independent loss of function mutations which are different but both result in los of function. This is different from homozygous in which the two mutations that cause loss of function are identical.
Hamizygous? That one I don't know. Correct spelling?
Maybe you are asking about hemizygous. This one refers to a state when an organism has just one allele of a gene, as it is with most of the alleles than men carry on chromosome X.
That is right. Hemizygous means basically having a single copy of a chromosomal region instead of the normal two. Although it is mainly used to refer to X-linked genes in males (in which hemizygousity is the norm), it is also used in patients with deletions in autosomal chromosomes.
Is 'nullizygous' specifically related to mouse or cell work? Ive never heard it used in a (medical) human mutation context
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