I have been working on producing skin safe glue to graft within a PVA-Carboxymethyl Chitosan or PVA-Sodium Alginate hydrogel.
I originally began my research with mussel inspired adhesion - by forming hydrogen bonds on catechol groups of polydopamine. I recognized the limitations of this method of adhesion due to the oxidation of dopamine as well as limited adhesive properties.
I am now working on Dusky Arion Slug slime inspired adhesion, discussed in a research paper from Harvard University. Article Tough adhesives for diverse wet surfaces
Positively charged chitosan, together with a coupling reagent such as transglutaminase should provide interactions between positively charged chitosan and negatively charged skin tissue, and covalent bond for sufficient adhesion.I am having difficulty producing a proper adhesive by combining positively charged chitosan (by dissolving chitosan in an acid buffer of acedic acid), and a 4:1 water-transglutaminase slurry.
If I cannot figure out how to create slug inspired adhesion I will move on to using cyanoacrylates as my skin safe glue.
Thank you for your help.
Dear Ricky Dua, I strongly advise to follow the last option. Cyanoacrylates skin adhesives are well investigated over the last decades, the chemistry is well understood, and they allow to tune the structure and reactivity to meet the required flexibility-performance. My Regards
There are many more products and constituents for use as skin glue. Literature checks out hopefully will result in multiple kinds of these products and their product-base. You need to check their constituents, composition, and formulation to figure out your take. Latex, natural rubber, etc. have been extensively used in various formulations for the purpose of the cosmetics and cosmeceuticals segments. Cyanoacrylates are also one of them BUT are toxic.