In many cases, neurological score and infarct volumes of MCAo/reperfusion (M/R) induced brain damage correlates. I mean if infarct volume is improved so does the neurological functions. However, sometime I experienced that there is no change in the infarct volumes but the neurological deficit is improved after drug treatment in M/R mice. For the confirmation I repeated the experiment but get the same results. I am using modified neurological severity score (mNSS) that is 18 point scaling for neurological deficit evaluation. To strengthen my findings, I need some published proof. Could you please help me? I have got 1 paper (but low impact journal) and need few more.
Endothelin B receptor agonist, IRL-1620, reduces neurological damage following permanent middle cerebral artery occlusion in rats
Mary G. Leonarda, b, Seema Briyala, Anil Gulatia, b,⁎
aMidwestern
Transfusion of CXCR4-Primed Endothelial Progenitor Cells Reduces Cerebral Ischemic Damage and Promotes Repair in db/db Diabetic Mice
Ji Chen1,2., Jianying Chen2., Shuzhen Chen1., Cheng Zhang1, Liangqing Zhang2, Xiang Xiao1, Avik Das1, Yuhui Zhao1,3, Bin Yuan1,2, Mariana Morris1, Bin Zhao2", Yanfang Chen1,2*
Several answers:
1. Clinical mismatch between radiology and clinical impairment scores is well described, e.g. see Ebinger et al. Stroke. 2009;40:2572-2574.
2. Not all experimental interventions will be 'neuroprotective', i.e. reduce brain damage. Some will enhance recovery (i.e. plasticity rather than changing cell number), lead to regeneration (increase new cells) etc.
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