Have anyone treated diphenhydramine (DPH) in rats or mouse animal model?

07 April 2017 1 2K Report

I am looking for the possible dose and duration of an antihistamine (DPH) treatment in rats. I could not find the enough references on rat/mouse models. If somebody have worked on it, please kindly share the information.

Gert Fricker

J Pharmacol Sci. 2016 Apr;130(4):212-8.

Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats.

Neurosci Lett. 2010 Feb 26;471(1):38-42.

Assessment of the rewarding effects of dimenhydrinate using the conditioned place preference paradigm in mice.

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