In early May 2020, a study by Korber et al reported the emergence of a SARS-CoV-2 mutation (Spike D614G), one of several Spike (S) mutations that have been discovered. SARS-CoV-2 infections with this mutation have become the dominant viral lineage in North America, Europe, and Australia. The significance of the D614G mutation in terms of factors such as transmissibility, virulence, antigenicity, and potential treatment resistance is poorly understood.