The ester of epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG), is the main and most significantly bioactive polyphenol found in solid green tea extract has been argued to have key (1) anti-inflammatory properties, (2) antiatherogenic properties as well as (3) protective effects against neuronal damage and brain edema. Has it been shown that this compound has a positive impact on dementia? What are the proposed mechanisms of action of this compound on the nervous system?
Dennis
Dennis Mazur
Reference:
Journal: Infect Agent Cancer. 2017 Jun 19;12:36. doi: 10.1186/s13027-017-0145-6. eCollection 2017.
Title: The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice.
Authors: Cascella M, Bimonte S, Muzio MR, Schiavone V, Cuomo A.
Dennis
Dennis Mazur
Hi Dennis.it may be was controlled by the signaling pathway p38MAPK/NF-KB..please follow this mechanism
Hope it helps
- http://www.sciencedirect.com/science/article/pii/S0925443911002298
- https://www.researchgate.net/publication/305817899_Polyphenols_in_dementia_From_molecular_basis_to_clinical_trials
- https://www.researchgate.net/publication/270288652_Protective_action_of_green_tea_catechins_in_neuronal_mitochondria_during_aging
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