I am working with hydrophobic nanoparticles and would like to suspend them in aqueous solutions without having to modify the surface of the particle with surfactants similar to Tween. I am currently looking into potentially using an organic solvent+water combination and allowing the solvent to evaporate, but I'm not sure how long the particles would stay suspended before crashing out or if it would even work and is possible.
Has anybody been able to do this using an evaporation method? I am also open to specific buffers, I just again do not want to end up coating the particles or modifying the surface. I currently am trying to work on suspending them in sodium acetate, but might need a super high concentration.
Anything helps- thank you!
Jade White
Any added molecules will change the surface of your hydrophobic particles by adsorption if you want to suspend them. You can stabilize them with tween. Then you can precipitate them in a centrifuge or filter them through a membrane and wash the surface from the surfactant with water or alcohol. Then dry them in the air.
Да, можно вначале поместить гидрофобные частицы в растворитель, а зетем заменить его на воду, постепенн добавляя воду или добавив воду, испарить растворитель.
Suspending hydrophobic nanoparticles in aqueous solutions without surface modification can be challenging; using an organic solvent-water combination may provide temporary dispersion, but particles could agglomerate as the solvent evaporates. Alternative methods like aerosol-to-liquid collection or optimizing high-concentration buffers, along with careful sonication, may offer more stable suspensions without altering the nanoparticles' surfaces.
Without surface modification, suspending of hydrophobic particles in aqueous solution like water seems practically impossible. However you may perform it by using ethanol:water mixture as aqueous solution. It will surely help you to do the required experiment.
Best wishes
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