Hi
I am carrying out a PHD investigating ‘The efficacy of Probiotic Supplementation on key neurotransmitters involved in Endurance Performance via manipulation of the Gut Brain Axis’.
As part of my research I aim to investigate the cause of perceived fatigue in endurance athletes. Potentially levels of plasma Tryptophan to establish Serotonin levels, I was also hoping to measure dopamine levels after a exercise protocol as a decrease would indicate fatigue.
My question therefore, is if there is biomarker to test for dopamine, was thinking tyrosine but can not seem to find papers on this.
Potentially an increase in adenosine would also indicate a decrease in dopamine
Any suggestions would be greatly appreciated?
Kind regards
As you know, dopamine, like other catecholamines, is broken down by an intra-nuronal enzyme called monoamine oxidase (MAO) and or an extracellular enzyme called catechol-O-methyltransferase (COMT). After decomposing, they make a substance called Homovanilic acid (HVA). By measuring it in cerebrospinal fluid, plasma or urine, the activity of dopaminergic neurons can be measured.
these articles maybe useful
Article Sansoninto attenuates aggressive behavior and increases leve...
Article Homovanillic acid in CSF of mild stage Parkinson's disease p...
best regards
Hi Maryam Rahimi-Tesiye thank you for the response and papers. Much appreciated
Article Biomarkers to detect central dopamine deficiency and disting...
https://www.theroyal.ca/news/clinical-biomarker-discoveries-dopamine-and-noradrenaline-impact-schizophrenia-and-alzheimers
Article Cerebrospinal fluid and blood biomarkers for neurodegenerati...
- Badges
- Science topic
- Similar topics
- Linguistics
- Composition Studies
- Publication