Good day scholars. Please I will like to know the mechanism of action or the antigenic binding sites of anti-trypanosomal drugs?

19 December 2022 1 7K Report

Drug mechanism of action and the site of action against any organism is important for the development of new and effective therapeutics.

John Carter

There are two drugs for treatment of Chagas: benznidazole and nifurtimox. Both work primarily by generating superoxide radicals, similar to metronidazole. While mammals detoxify superoxide (albeit with significant side effects), protozoans suffer fatal DNA damage.

I know of no vaccine candidates for Chagas. Like other apicomplexans, trypanosomes feature highly variable, highly immunogenic "decoy" surface antigens that facilitate immune escape.

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