I had two questions on an article at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#:~:text=Single%20GABA%20administration%20(100%20mg,(C%2CD)). Would appreciate your input.
1. I thought GABA in supplement form doesn't cross the blood-brain barrier, or if so, only in small amounts, then why does it seem to function in the mice of this article?
2. Article says “The combined use of GABA/l-theanine (100/20 mg/kg) showed a decrease in sleep latency (20.7% and 14.9%, respectively) and an increase in sleep duration (87.3% and 26.8%, respectively) compared to a single administration of GABA (100 mg/kg) or theanine (20 mg/kg).” When referring only to the GABA/l-theanine 100/20mg/kg dose, why are two percentages mentioned: 87.3 and 26.8%?
3. Figure 2(D) shows GABA(100mg/kg)’s effect on sleeping time to be lower than L-theanine (20mg/kg), but looking at Figure 1(C) and 1(D) it appears GABA(100mg/kg)’s effect is greater. So why does Figure 2(D) show GABA(100mg/kg) to be smaller?
Thank you,
Joe.
1- Please read these articles to understand GABA and BBB
a) https://www.mcgill.ca/oss/article/health/gaba-supplements-glorious-gimmicky-or-just-garbage
b) Article Effect of oral γ-aminobutyric acid (GABA) administration on ...
2- You may want to differentiate between sleep latency and duration of sleep to understand the figures of the article you mentioned.
Hello, thank you for your response. That clarified the question on GABA and BBB.
However, for the second question, four percentages are mentioned. If it were just the GABA/L-theanine's effect on sleep duration and latency, one would expect only two percentages.
Also, Looking at Figure 4(C), why is the L-theanine bar showing the same height as the GABA/L-theanine but it's still considered insignificant compared to control while GABA/L-theanine is significant?
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