Some of them did the drug release study by Franz diffusion cell . In some other papers people done drug release study by swelling the material into the saline and recording the readings in particular time intervals. But both are completely different environment. Which is correct method to evaluate the drug release for wound healing application.
kindly share your opinion. Thank you
The saline swelling method is often more representative of wound healing applications, as wounds typically have a moist environment with exudates. This method better simulates the conditions a wound dressing or drug delivery system will encounter in situ, leading to more accurate release profiles for such applications.
The Franz diffusion cell could also be used if the study’s goal is to understand permeation through intact skin. However, for direct wound applications, the saline method aligns more closely with physiological conditions and may provide a more reliable indication of drug release behavior in an actual wound setting.
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