The normal blood pH regulated between 7.35 and 7.45, it would be better if u do with pH 7.4
The pH should be as close to physiologic 7.4 as possible. What is acceptable depends also on factors such as the volume of the single dose and if it is a bolus or infusion. With low volumes wider range of pH can be tolerated, since blood has some buffer capacity, although injections may be painful. For larger volumes using non-physiological pH can cause phlebitis or chemical reaction with catheters. The very general guideline is between 5.0 and 9.0, but it depends on many factors. So I guess you should try with buffers or different salts perhaps. And don't forget about osmolarity.
Dear Kanchan Parwani
It depends on the type of extraction.
"i.v." solutions have pH = 7.4 and no need of correction.
In some cases I use phosphate buffer.
Good luck with that
Mihai Ionicã
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