While using antibiotic Ceftriaxone in mice for CLP model of sepsis, it is always used with some other antibiotics like metronidazole or clindamycin and not alone. Can't we use ceftriaxone alone at higher dose.
Thank you
Komal,
Ceftriaxone is inactive against most strains of Pseudomonas aeruginosa, many strains of Enterobactor cloacae and methicillin resistant strains of staphylococci. This is the primary reason to utilize dual therapy.
Regards,
Christopher
Ceftriaxone is an excellent antibiotic for the treatment of Pneumonia, including the coverage of what we call the "typical" bacteria" (e.g. Pneumococcus, Haemophilus Influenza, and Moraxella Catarrhalis). On the other hand, it does NOT cover, NEITHER "Atypical " germs (e.g. Legionella and Mycoplasma), therefore needing the addition of a Macrolide or a Quinolone, NOR the Anaerobes Bacteria from the oral cavity, resulting in an episode of Aspiration Pneumonia (e.g. Peptococcus and/or Peptostreptococcus), thus needing an Antibiotic like Clindamycin or Piperocillin/Tazobactam. Moreover, a study has already shown that the combination of Ceftriaxone-Azithromycin decreased the mortality of an episode of Pneumococcal Pneumonia, compared to Ceftriaxone-Placebo. The reason for this finding was the proven immunomodulatory effects of Azithromycin, including an anti-inflammatory mechanism of action, of the latter Rx.
Jean-Francois Mathieu, B.Sc. M.Sc. M.D. LMCC, Clinical Professor, Faculty of Medicine, University of Montreal; Attending ICU Physician, Verdun General Hospital.