I am very interested to follow answers of colleagues.

Interesting poser

It's the body's attempt to fight illness. So when we treat fever with antipyretics, like acetaminophen (Tylenol) or ibuprofen, we only handcuff an important part of our immune response. Although it might seem counterintuitive, several studies have now shown that antipyretics increase the severity of infections.

Source: https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.thedailybeast.com/let-it-burn-why-you-should-let-fevers-run-their-course&ved=2ahUKEwj_6YK6wpPgAhUJa1AKHZ60Cz0QFjABegQIDhAF&usg=AOvVaw3Y3RQW1ZCTJZwqhfEA3En-

I know the rule for children: do not try to reduce fever until it is over 38

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Fever means we are healthy as our body is fighting sickness. However the brain will suffer with fever. Taking aspirin is the wrong solution as it stops the body from fighting. So let's do like our grandparents who used to put cold towel on the front to cool down the brain. The cure will take time but any good thing needs time and maturity.

Beyond certain level, fever must be controlled.

Yes u r right sir . Fever is the indication of auto-immune response towards infections. Thats why i have never taken any medicine in moderate fever.

Immunology goes beyond concluding with a study when in fact, it was not a clinical trial with multiple studies. Did the study assess effect of pro-inflammatory cytokines on health?. Adverse effect of pro-inflammatory cytokines in diseases may sometimes worth a whole study in opposing this stand, on its own. Fever is not an ordinary trigger of immune responses but goes with body pains due to these cytokines. How does growing cells ex vivo replicate this immune trigger without mentioning the other adverse effect in humans?. Do lawn-cell growths speak for the living systems?

Did the study use living humans other than stem cells or rather cultured cells where in actual facts various challenges in translating that finding are abound...?

You cannot jump into conclusion with a single study which is subjective... have they considered individual physiological variation... medicine goes beyond interpreting it like this....

My opinion.

Fever is usually a sign that the body is fighting infection. When the immune system of the body is activated by a germ, many reactions occur in the body. Fever is one sign of these reactions. Fever is not a disease or disease in itself.

Prevent fever by reducing your exposure to infectious diseases. Here are some tips that might help:

More than wash your hands and teach your children to do the same, especially before eating, after using the toilet, after spending some time in the hustle or around a sick person, after fondling the animals, while traveling in public transport.

Teach your children how to wash your hands well, so wash each hand from the front and back with soap and wash them thoroughly with clean water.

Use the hand sanitizer several times in the absence of water and soap.

Try to avoid touching the nose, mouth, and eyes, because these are the basic ways to enter bacteria and viruses into the body and thus cause infection.

Cover your mouth when you cough and your nose when sneezing, and teach your children to do likewise. As far as possible, keep away from others when coughing or sneezing to avoid transferring germs to them.

Avoid sharing cups, water bottles and utensils with your child or children in general.

Good contributions

Yes, fever boosts the immune system of the body, but high fever i.e. above 105° F is life threatening and can result in convulsions and possible death or permanent brain damage. That's why it becomes necessary to reduce or control fever. Please take a look at the following PDF attachment.

Dear all

fever is a good indicator that the immune system is doing well. Endogenous pyrogen in human being like Interleukin One and IL-6 act a to stimulate thermal regulatory center in the brain to produce fever. On the other hand, controlling of fever is so important because high fever may threads the life . Best regard

Fever is a cardinal response to infection. A fever can help immune system fight infections . A higher temperature in the body speeds up the functioning of cells, including the ones that fight illness. They can respond to invading germs faster. Also, higher body temperatures make it harder for bacteria and viruses to thrive in the body.

Hello, It's the body's attempt to fight illness. So when we treat fever with antipyretics, like acetaminophen Tylenol or ibuprofen, we only handcuff an important part of our immune response. Although it might seem counterintuitive, several studies have now shown that antipyretics increase the severity of infections.

Yes, it boosts immune system. Also Following well explain information of all people.

Dear all thank you very much for contributing to this topic

Yes, i agree to this point presented by Arvind Singh , Hazim Al Dilaimy Hazim Al Dilaimy Kamoru A. Adedokun Zainab A Makawi

I feel a little fever is a protective response like 101C which help through various mediators like interfereon and interleukin help reduce the inflammation. However very high grade fever needs to be helped with treatment.

However, the current ambitioususe of medicine including antibiotics has resulted in not only resulted in antibiotic resistance but has also not been helping the natural body immune response.

So caution need to be exercised whenever we are using antipyretics as we are also not allowing the immune system to work naturally

Regards

More importantly, according to the AAP, a fever can help your child's body fight off infection. Many illness-causing microbes do best at the body's normal temperature. ... A small but growing body of research shows that letting a fever run its course may reduce the length and severity of such illnesses as colds and flu.

With cold and flu season almost here, the next time you're sick, you may want to thank your fever for helping fight off infection. That's because scientists have found more evidence that elevated body temperature helps certain types of immune cells to work better.

Very nice topic for the discussion. I hope to get more answers by the experts.

Thank you Dr. Arvind Singh Sir for sharing the valuable research aarticle.

Fever is one of the major cardinal signs of inflammation. It's presence shows the immune system is activated to infection. Hence it helps to modulate by engaging some interleukin. However, its presence could go beyond the threshold and as such causing a negative feedback mechanism.

There are different ways to reduce fever without necessarily treating with antipyretics. Treatment using drugs that affects the CNS could lead to further deterioration.

Fever is one of the major cardinal signs of inflammation. It's presence shows the immune system is activated to infection. Hence it helps to modulate by engaging some interleukin. However, its presence could go beyond the threshold and as such causing a negative feedback mechanism.

There are different ways to reduce fever without necessarily treating with antipyretics. Treatment using drugs that affects the CNS could lead to further deterioration.

Interesting contributions

The brain causes the body to spike a fever when illness is sensed in order to begin production of antibodies to fight infection.

Thank you very much

However, it seems a little fever and release of cytokines and other inflammatory markers is a better thing but not too much

Dysregulated over release of cytokines is not desirable

Article Clinical implications of dysregulated cytokine production

So not every fever may require suppression or else our immune response may get suppressed

Regards

I found this presentation picture which looks more explanatory and address the point in discussion

I think fever is very scary for parents, especially for children under 3 months and if the fever lasts more than five days. Should we not worry about child’s fever?

With cold and flu season almost here, the next time you're sick, you may want to thank your fever for helping fight off infection. That's because scientists have found more evidence that elevated body temperature helps certain types of immune cells to work better.

Good contributions

No!

Certainly, fever is a defense mechanism of innate immunity that has persisted in the evolution of vertebrates. Not only is it important to eliminate the microbial load, but it also allows us to detect that something is wrong in our organism. Even febrile peak patterns help diagnose certain diseases. for example: Pel-Ebstei fever. Nocturnal or evening, it is observed in the disease of Hodking and Brucellosis, neoplasias such as lymphosarcoma and reticulosarcoma, as well as in tuberculosis. We must not forget that fever is not always synonymous with infection. Many inflammatory and autoimmune diseases can cause fever without infection.

However, in patients with high fever (> 39 °C ) sustained high temperatures can be harmful, for example can cause convulsion, anorexy, mental confuction, cefalea, etc.

The decision to treat or not treat a fever as a symptom is a decision that the doctor must make, case by case, according to the diagnosis, the intensity of the fever and the risk-benefit.

Aim to The body by raising its temperature to resist infection by killing bacteria, some types of which do not tolerate heat caused by fever. The fever also activates the immune system, which enhances its attack on and elimination of bacteria. Also, fever forms an early warning that tells you of an infection

If someone contracted a virus or perhaps bacterial infection, fails to recover in the normal/expected time frame, or bacterial treatment is not begun till several months post infection and the person goes onto develop post infectious disease syndrome/fibromyalgia or ME/CFS (persisting 1 yr + post infection. If using pyretics for ongoing management of flare ups/relapses, commonly muscle aches and low grade fevers interspesed with other symptoms, would pyretics potentially be reducing their immune systems response? ie low grade fevers with these conditions aren’t persistent, unrelenting low grade fevers for 2 weeks or more. Is this purely the immune system response going haywire ?

We should not try to reduce fever unless it is causing unbearable distress or life-threatening complications. Most of the time it does not cause any such thing. Brain damage is a possibility in heat strokes but not in infection-caused fever. Up to 108 F fever is not an issue during infections. Usually, that's extremely rare -may be observed only if you have got some novel pathogen. Fever is actually a warning system in the body just like we have for the weather. Its an enabler to disease resolution and decreasing fever is associated with more complications and mortality. You may like to check for yourself different references found in this preprint Preprint WHO Fever Management Guidelines: Challenges in Harnessing th...