Could we ever reach a conclusion about Fermi Paradox?

Ideas:

-we could be just too distant from any other advanced life.

-they're already came here (still here, or lost heart then left, ... etc).

-they're already on their way here.

-they know about us, can reach us, but choose to leave us be for one reason or another.

-Earth is more than 70% covered with water, so simply any other civilization could see earth as a water planet only?

- detection issues: noisy cosmic environment, weak EM signals, highly shifted wavelengths... etc.

-chemical reasons: our sun is far from the galactic center meaning the metallicity in our cosmic neighborhood is different from other distant regions which also could mean there are other life forms than carbon-based life.

- possible differences in the carbon based life foms itself: could there be intelligent life forms that have different senses?

-Time: this factor only has a fundamental role in life (intelligence) evolution; in many different ways, some are clear and straightforward, others are vague.

Each of these can bring up so many other possibilities! So is is possible really to find an answer for Fermi question?