Hi there,
I am currently doing research about time restricted feeding(TRF). And here is the anatomic photo got directly on the TRF mouse(TRF with chow food). There are distributing lots of macroscopic white spots. I am wondering what are they? By the way, this mouse was sacrificed on the morning without fasting. Lipogenesis? glycogen accumulation? Fibrosis?
Hope someone could answer this question! Thank you in advance.
Hello Kanru Sang
The white spots observed on mouse liver could be because of some diseased state. For instance, Ectromelia Virus (Mousepox) can cause acute hepatocellular necrosis resulting in white spots on the liver. There is also another disease known as Rabbit Fever which is a bacterial disease caused by Francisella tularensis resulting in small white spots on the liver.
Progressive injury to the liver caused due to chronic P-selectin deficiency can result in white spots. In mice, P-selectin may protect from liver fibrosis.
The white spots may also be a sign of hepatosplenomegaly (caused by a number of conditions like Glycogen storage disease, Obesity, Diabetes). In such case, granuloma nodules may be observed on the liver surface, as indicated by white spots.
Best.
Dear Canru Sang
One of the main cause of infection of mouse liver is most liketly to be helicobacter " Helicobacter hepaticus; H. bilis and many others"
Please make histopathologic section with HE stain together with the macroscopic picture. It would be helpful for the diagnosis.
Best wishes
Some infections can induce white spots. But it is also important to discard tumors and amyloid proteins
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