There is no simple answer. Specificity for one target may be desired in order to reduce side effects caused by inhibition of other targets. However, there could also be a therapeutic benefit to inhibiting multiple targets, as well as a reduced probability for the development of resistance.

Indeed there is no simple answer but, could you please through some light on which one to give more preference.

Targeting multiple signalling pathways may lead to overt adverse effects, however it is an aim in polypharmacology.

Hello

I agree with researchers , the links here you can help you .

Good Luck 

https://www.hindawi.com/journals/isrn/2014/939378/

https://www.ncbi.nlm.nih.gov/pubmed/20890056

http://www.nature.com/nrc/posters/pathways/index.html

https://www.ncbi.nlm.nih.gov/pubmed/155231

http://jivaresearch.org/research/curcumin/Targeting_cell_signaling_pathways_for_drug_discovery-_an_old_lock_needs_a_new_key.pdf06

Bundle of thanks to all.

I think selective target is more encouraging otherwise it may lead to unwanted side effects.