Could we think about drug molecules without small molecules? I mean less introduce foreign particles in our body.
Yes, you can opt for a smarter drug-delivery approach; maybe nanoparticles. Research is also being conducted in to ensure site-specific drug delivery using lesser dosage and higher efficacy.
It depends of what are small molecules. Indeed, we are living now in a highly "chemical" environment. Therefore, drugs are not the main source of exogenous particles for my opinion.
Actually, orally administered drugs should be relatively small in addition to other parameters in other to be qualified. At least a molecular mass less than 500 daltons according to Lipinski's rule of five. In this context, we cannot do without small molecules in drug discovery and development. Small molecules are highly needed when it has to do with orally administered drugs
The question is somewhat confusing. "Drug molecules without small molecules and less amount of foreign particles." If you want to develop an oral drug small molecule is the best choice.
Priyodip Paul , Thank you for the suggestion. Let's forget about a chemical-based drug synthesis. Any other way can we offer treatment to the people?
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