Does Tween 20 have antimicrobial potential?

07 June 2022 1 6K Report

I'm preparing a Eugenol nanoemulsion using Tween 20 as the surfactant. Ethanol is employed as cosurfactant. I wanted to know if Tween 20 acts as an antimicrobial agent and can contribute to the overall antimicrobial activity of this NE

Phil Geis

Ethanol as a surfactant.? Or solvent.

The immediate effect of tween 20 depends on the systems (e.g. https://www.sciencedirect.com/science/article/abs/pii/S0023643809000590).

Indirectly, Tween 20 hydrolysis (via target microorganisms esterases) offers C12 lauric acid/laurate that has direct antimicrobial potential. If you find this an issue, true Tween 80.

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