Thanks for your in depth answers gentlemen. It really helped with my understanding of competitive binding to ACEII by the glycoprotein spike protein of coronaviruses.

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If the RAAS pathway is blocked total peripheral resistance will drop and sodium re-uptake will not be induced in turn water retention is lowered, thus lowering venous return and will have the above queried on affect the Frank-Starling mechanism.

Thanks again and all the best in these troubling times.

The viruses targeting of the RAAS system is the inhibitor and administration of agonists are now showing to have some improvement in severe patients.

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