I have a question, because with a research team we want to carry out a nanoencapsulation by means of a microfluidizer, and then dry it by a spray dryer. The model thought to buy is Yamatho ADL311-A, but we have a doubt because the model in its technical sheet shows particle sizes which are large for the objective we have in mind (Minimum 406 μm). I have been reading investigations which obtain particle sizes between 210-280 nm, also using microfluidizer and spray dryer. Will the spray nozzle not affect the size? Or what models of spray dryer do you recommend using?
Check https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974141/
Also check https://www.researchgate.net/publication/318797912_Nanocapsules_formation_by_nano_spray_drying
Not affect the size of the nanocapsule because it depends on the atomizer used.
Please see a spray dryer guide by BUCHI with the link below. This will answer this question.
https://www.buchi.com/en/knowledge/applications/spray-drying-basic-theory-applications
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