Allosteric binding sites are different from the active sites. If insulin receptor has this characteristic then it will be easy to target the receptor in insulin associated disorders.
I did a simple organic reaction where I left with excess of Polyhydroxymethylsiloxane (PHMS) in the final product solution. I tried to extract it with aqueous layer, but I failed. Let me know, if...
08 September 2015 2,858 3 View
I have a protein-protein complex and therefore, need a visualiser to look at those amino acids which are at interface of these proteins. However I am also interested to see the interactions...
06 July 2015 9,841 15 View
when we do superpose of 3 pdbs together (1 on 2, 2 on 3, 3 on 1) and after that if we change the sequence of superposition, will there be any possibility to see the change in RMSD value (before...
05 June 2015 8,201 7 View
I have 6 receptors and only 1 ligand. In the meantime I interested to do the docking in all these receptor. Is there any way where we have a generalised way to dock this compound to these receptor...
10 November 2014 4,551 12 View
Hi I am looking for a MD simulation calculations for Small molecule-Protein interaction. But right now I am limited to Windows. So please let me know if there is any software which is useful in...
10 November 2014 3,958 10 View
I want to dock a carbohydrate molecule as a ligand on a protein. What is the best scoring function/force field that I can use for this type of docking?
10 November 2014 3,253 5 View
I want to know about the tools available for searching for a protein or receptor for a known ligand.
09 October 2014 6,300 9 View
What is the best reagent which can be useful in the reduction of 2,4-dinitrobenzaldeyde?
07 August 2014 1,894 16 View
What we know is that the proteins get acetylated at lysine moiety. But looking into the structure, we got around more than one lysine moiety. Then how it can be possible to find out which lysine...
07 August 2014 1,253 6 View
Recently I was encountered with a problem where structure shown in figure is not able to get converted to any product. May be possibly due to its resonance effect or any other effect between the...
06 July 2014 1,715 18 View
..
05 August 2024 4,407 0 View
I am trying to prepare samples for IP. The pellet size is good and I am using 1% Tx-100 and using a syringe to further lyse the cells and maintain protein-protein interactions. I keep having a...
01 August 2024 7,199 1 View
Continuous glucose monitors (CGMs) help patients and doctors make more timely management decisions by monitoring blood glucose levels in real time. An insulin pump provides continuous insulin...
07 July 2024 7,742 0 View
Is there a protocol to establish diabetic conditions in pre-osteoblasts cell culture?
18 June 2024 9,306 2 View
Comprehensive Overview of Myocardial Infarction: Etiology, E... How does the presence of diabetes affect the prognosis of myocardial infarction?
15 June 2024 1,038 3 View
Dear fellow researchers, We are conducting an ELISA with the "Cattle IGF 1 (Insulin-like growth factor) ELISA Kit" (Cat: ELK5630). Samples and reagents were prepared following the instruction...
13 June 2024 9,473 0 View
the prevalence of shoulder frozen is much higher in diabetic patients than non diabetic, and what will be the cause? There is many reports but still not will understood.
10 June 2024 3,270 3 View
Recently, I am preparing novel electrospun nanofibers for forward osmosis membrane preparation, I am facing following problems: 1. While testing water flux, there is little leakage, although the...
28 May 2024 8,510 2 View
Creating a conceptual framework for pregnancy outcomes involves identifying and defining the key variables that may influence maternal and fetal health during pregnancy. These variables provide a...
28 May 2024 3,196 2 View
Type 1 diabetes, the effect of peer support in self care efficacy, emotional well being
27 May 2024 4,325 0 View