Hi. I have a question of the MHCII expression in mammal. What I know so far is that the expression of MHCII is codominant, alleles from both mom and dad will be expressed. However, I would like to if the genotype of MHCII affect the phenotype. For example, would the MHCII wild type animals express more MHCII protein than the MHCII heterozygous animals? Also, would the MHCII WT animals process more antigen and have a stronger immune response than the MHCII heterozygous animals? Assuming only one specific type of antigen is processed in this case.

It will be very helpful if you can post some related literature. Thanks for your time!