Does the Edman reagent react with the Proline at N- terminus? Does it react with Proline at any position other than N- terminus?

Varatharajan Sabareesh @Varatharajan-Sabareesh

02 July 2014 1 2K Report

It is known that Edman reagent (PITC) reacts with primary amino group. However, is PITC capable of reacting with secondary amine, i.e., proline?

Deepti Agrawal

Yes PITC Produces stable products with all amino acids, including proline...

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