Just wondering if the degradation of PLLA will induce fibrosis and encapsulation of macro-scaled devices (not nanoparticles or microparticles). Thanks!
Short-Term and Long-Term Effects of Orthopedic Biodegradable ...
https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC)
by AR Amini - 2011 - Cited by 44 - Related articles
These polymers can be synthetic or natural and degrade through ... group, which includes polyglycolide (PGA), polylactide (PLLA), and their co-polymer ..... Biodegradable polyester implants induce afibrotic walling-off phenomenon after ...
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Biomedical Applications of Biodegradable Polymers - NCBI
by BD Ulery - 2011 - Cited by 613 - Related articles
Jun 15, 2011 - These changes can cause long-term host responses to these biomaterials to .... While possessing more desirable degradation properties than PLLA, ..... cystic fibrosis and lung cancer (lung mucosa) and HIV (vaginal mucosa).
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Biomaterials & scaffolds for tissue engineering - ScienceDirect
by FJ O'Brien - 2011 - Cited by 516 - Related articles
Mar 5, 2011 - This will determine how either the scaffold or the tissue engineered construct will be stored. ... In addition, concerns exist about the degradation process of PLLA .... In addition, autologous chondrocyte implantation (ACI) and matrix-induced ... that mechanically mimic a post-infarct fibroticscar, cells overstrain ...
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Degradation Rate of Bioresorbable Materials: Prediction and Evaluation
https://books.google.com.au/books?isbn=1845695038
F J Buchanan - 2008 - Technology & Engineering
within degrading polylactide implants (De Jong et al., 2005). Bovine collagen had been found toinduce antibody production and clinically unwanted ... Fibrosis/ fibrous capsule formation In the presence of a biomaterial, fibrosis or a fibrous ... Multiple factors can influence the thickness of the surrounding fibrous capsule.