I performed a molecular docking analysis of my designed structure towards anaplastic lymphoma kinase. Results showed all structures have a high binding affinity to anaplastic lymphoma kinase compared to crizotinib. Then, the structures were synthesized and confirmed using NMR, mass spec, and IR. However, the synthesized compounds have low inhibition in the A549 cell line.
Malcolm Nobre
Hello Benhur Medija
Anaplastic lymphoma kinase inhibitors seem to have low inhibition in the A549 cell line. You can refer to the research article below.
https://www.redjournal.org/article/S0360-3016(20)33018-2/fulltext#relatedArticles
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