Dear Rupak

Interesting question. There are few specific reports about that:

Case report: oseltamivir-induced resistant pandemic influenza A (H1N1) virus infection in a patient with AIDS and Pneumocystis jirovecii pneumonia.

van Kampen JJ, Bielefeld-Buss AJ, Ott A, Maaskant J, Faber HJ, Lutisan JG, Boucher CA.

J Med Virol. 2013 Jun;85(6):941-3. doi: 10.1002/jmv.23560.

PMID:

23588718

[PubMed - indexed for MEDLINE]

Related citations

Select item 218133182.

Genotyping of a nosocomial outbreak of pandemic influenza A/H1N1 2009.

Rodríguez-Sánchez B, Alonso M, Catalán P, Sánchez Conde M, González-Candelas F, Giannella M, Bouza E, García de Viedma D.

J Clin Virol. 2011 Oct;52(2):129-32. doi: 10.1016/j.jcv.2011.07.001. Epub 2011 Aug 2.

PMID:

21813318

[PubMed - indexed for MEDLINE]

Related citations

Select item 211394863.

Severe 2009 pandemic influenza A (H1N1) infection and increased mortality in patients with late and advanced HIV disease.

Ormsby CE, de la Rosa-Zamboni D, Vázquez-Pérez J, Ablanedo-Terrazas Y, Vega-Barrientos R, Gómez-Palacio M, Murakami-Ogasawara A, Ibarra-Ávalos JA, Romero-Rodríguez D, Avila-Ríos S, Reyes-Terán G.

AIDS. 2011 Feb 20;25(4):435-9. doi: 10.1097/QAD.0b013e3283434844.

PMID:

21139486

[PubMed - indexed for MEDLINE]

Related citations

Select item 210392164.

Pandemic influenza A (H1N1) outbreak among 15 school-aged HIV-1-infected children.

Feiterna-Sperling C, Edelmann A, Nickel R, Magdorf K, Bergmann F, Rautenberg P, Schweiger B, Wahn V, Krüger DH, Hofmann J.

Clin Infect Dis. 2010 Dec 1;51(11):e90-4. doi: 10.1086/657121. Epub 2010 Nov 1.

I attached them on this message.

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Dear Sir,

Thank you for answering it with great detail along with attachments.

Regards

Dear Rupak

Please if you consider this answer appropriate, please upvote it using the green up arrow click. Thanks.

Best wishes,

Alfonso.

My opinion: clearly, H1N1 influenza virus infection has a more severe outcome in individuals who have no virus-specific antibodies against this particular genotype. The first H1N1 strains emerged in 1977, when the H3N2 strain was still most common, but persons who underwent previous H1N1 infection between the two Wolrd Wars were already not alive...Since H1 hemagglutinin is higly variable, when undergoing many points mutations, some H1N1 strain variants may escape the immune predominating memory response and could behave as very new strain. In HIV patients, with already impaired immune system, the problem of high H1 point mutation frequency acts at an even more dangerous manner. Furthermore, great majority of infuenza infected subjects succumb due to bacterial superinfection, since their bronchial epithelium cells as a rule conferring airway cleaning via ciliary movements, are absent and completly fail. When HIV patients are more sensitive to H1N1 infection, this may not be due a direct potentiation of the  replication of first virus by the second virus...The enhancement may indirect, via immune response failure or delay.