hello: i am not clear about your question where you say oxidative stress;

according to definition of oxidative stress :

By Dr Ananya Mandal, MD

Oxidative stress is essentially an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants.

I work on TMJ with my patients but have not heard about this before . at all!!!!

to give you the benefit of the doubt can you tell us what do you mean by oxidative stress and its effect on TMJ ie what do you mean please.

thank you

Best Wishes

Professor K.galil.DDS.,D.Oral&max fac Surg.,Ph.D.,FAGD.,FADI.,Cert.Periodntist (Royal College of Dental Surgeons)

visit DGOHE +itune to see the new Oral histology App fr the I phone,Ipad &I Pod touch 

Hi dear,  I think there could be a strong relationship based on the pathogenic role of oxidative stress and inflammation.  The attached article may be useful. 

My best wishes

Article Mir Sajad, Mohd Asif, Sadiq Umar, Jamil Zargan, Mohd Rizwan,...

Thank Dr. k.a Galil and Dr. Hala Hazzaa !! 

Please read "Temporomandibular Joint Dysfunctions and Bio-Materials: Design, Free Radical Defense and Mechanism In Vitro"

https://www.ecronicon.com/ecde/dental-science-ECDE-02-000049.php

and talk me about this!!!!

Hello Dr José Manuel Valdés Reyes ·

The authors say

the aim of this investigation is to evaluate the suitability and flexibility of the bio-active containing designer materials to act as an “in vitro” probe to gain insights into molecular origin of TMJ.

In this investigation we prepared and evaluated bioactive materials containing Chitosan/Hydroxyapatite, which have proven to be suitability and flexibility of the designer materials to act as an “in vitro” probe to gain insights into molecular origin of TMJ and more specifically excessive damage caused by oxygen centered radicals and the defense “build in” free radical defense mechanism of the functionalized bio-scaffolds on the molecular level and apply the newly developed materials for the development of new therapeutic treatment modalities in the TMJ therapy.

My reply

This is obviously not the so called western treatment where we treat TMJ with anti inflammatory drugs  or as I do we do  arthroscopic lavage of the TMJ .this treatment depends on having a scaffold material chitosan loaded with natural herbs or oils  and applied to the tmJ to detect  the so called molecular origin of TMJ .this is different what I would call molecular origin if TMJ to me molecular origin will be looking for signaling molecules like this

Various signalling pathways, as FGF, WNT and TGF-β pathways, regulate the processes involved in embryogenesis. FGF (Fibroblast Growth Factor) ligands bind toreceptors tyrosine kinase, FGFR (Fibroblast Growth Factor Receptors), and form a stable complex with co-receptors HSPG (Heparan Sulphate Proteoglycans) that will promote autophosphorylation of the intracellular domain of FGFR and consequent activation of four main pathways: MAPK/ERK, PI3K, PLCγ and JAK/STAT.

·        MAPK/ERK (Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase) regulates gene transcription through successive kinase phosphorylation and in human embryonic stem cells it helps maintaining pluripotency. However, in the presence of Activin A, a TGF-β ligand, it causes the formation of mesoderm andneuroectoderm.

·        Phosphorylation of membrane phospholipids by PI3K (Phosphatidylinositol 3-Kinase) results in activation of AKT/PKB (Protein Kinase B). This kinase is involved in cell survival and inhibition of apoptosis, cellular growth and maintenance of pluripotency, in embryonic stem cells.

·        PLCγ (Phosphoinositide Phospholipase C γ) hydrolyzes membrane phospholipids to form IP3 (Inositoltriphosphate) and DAG (Diacylglycerol), leading to activation of kinases and regulating morphogenic movements during gastrulation and neurulation.

·        STAT (Signal Trandsducer and Activator of Transcription) is phosphorylated by JAK (Janus Kinase) and regulates gene transcription, determining cell fates. In mouse embryonic stem cells, this pathway helps maintaining pluripotency.

The WNT pathway allows β-catenin function in gene transcription, once the interaction between WNT ligand and G protein-coupled receptor Frizzled inhibits GSK-3(Glycogen Synthase Kinase-3) and thus formation of β-catenin destruction complex.Although there is some controversy about the effects of this pathway in embryogenesis, it is thought that WNT signalling induces primitive streak, mesoderm and endoderm formation.[100] In TGF-β (Transforming Growth Factor β) pathway, BMP(Bone Morphogenic Protein), Activin and Nodal ligands bind to their receptors and activate Smads that bind to DNA and promote gene transcription.Activin is necessary for mesoderm and specially endoderm differentiation, and Nodal and BMP are involved in embryo patterning. BMP is also responsible for formation of extra-embryonic tissues before and during gastrulation, and for early mesoderm differentiation, when Activin and FGF pathways are activated.

The only thing I can relate to that paper is chitosan where one of my colleagues use it and hopes to use in periodontal research as barrier

This paper has nothing to do with molecular biology of TMJ it has to do with delivering substance on a substrate (chitosan ) and detecting what comes out on the substrate

this paper is not in my specialty.

my research with molecular biology and what i call molequar  biology could be seen in the review i wrote in a paper i entitled

Molecular Biology of Orthodontic Tooth Movement

i have attached the paper for your  enjoyment 

best wishes

Professor K.galil.DDS.,D.Oral&max fac Surg.,Ph.D.,FAGD.,FADI.,Cert.Periodntist (Royal College of Dental Surgeons)

visit DGOHE +itune to see the new Oral histology App fr the I phone,Ipad &I Pod touch 

Dear Dr,

Many thanks for your response!!! and the article "Molecular Biology of Orthodontic Tooth Movement" has very good information for me.

Thanks!!

Cordially