Specifically, papers in which they measure mitotic index or cell cycle length of colon cancer cells in primary tumors? And reviews on the mutations (types, incidence) that confer chemoresistance to classical drugs used for colon cancer treatment (5-FU, CPT-11,I-OHP)?
38. Schumacher M, Hautzinger A, Rossmann A, Holzhauser S, Popovic D, et al. (2011) Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice. Cancer Invest 29: 396–404. doi: 10.3109/07357907.2011.587071.
This article is related to the effect of flavones but it also touches on chemoresistance and differential response
Differentiation status is very important in determining tumorigenicity and cellular response.
High-expression levels of Aldehyde dehydrogenase (ALDH) is regarded as a very specific marker used in the detection of cancer-initiating cells as subpopulations in tumors, as well as in the determination of tumorigenic status in established cancer cell lines. Highly tumorigenic cells that express high levels of ALDH: Caco-2 and HCT-116
You may find this info in the following references:
Neumeister V, Agarwal S, Bordeaux J, Camp RL, Rimm DL (2010) In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis. Am J Pathol 176: 2131–2138. doi: 10.2353/ajpath.2010.090712.
Lin L, Liu Y, Li H, Li PK, Fuchs J, et al. (2011) Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030. Br J Cancer 105: 212–220. doi: 10.1038/bjc.2011.200.
I do not know whether the attached articles could be (still) of help.
Best regards
Robert
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