What I am aware of is that experimental data suggest the existence of REM sleep deprivation / REM rebound phenomenon related immunomodulation, in terms of circulating cytokines  profile changes and neutrophils cytotoxicity reduction. Look at thr literature for more info!

Many Thanks Theodoros,

Indeed, I read some papers showing that sleep loss induces an immunomodulation such as for instance a functional alteration of monocyte proinflammatory cytokine responses (e.g. Sleep Loss Activates Cellular Markers of Inflammation: Sex Differences - Brain Behav Immun. 2010 January ; 24(1): 54–57.).

Hovewer, I failed to find a sleep modulation of circulating LPS-antibodies. My interest is focussed on the putative role of such a (down) modulation in the development of exertional heat stroke (EHS) since numerous symptoms of EHS are those of sepsis and one of the major predisposing factor of EHS is sleep loss.

Thanks again,

Lo

Then we could set up a study for the next summer!!! We have plenty of those patients unfortunately ...

Best wishes

Theo