It is expected that the rate of drug release will be affected by the increase in polymer (albumin) content in the nanoparticles. composition of 1:5 is expected to release larger percentage of drug compared to the composition of 1:300.
For similar study, please see the publication entitled "Albumin nanoparticles coated with polysorbate 80 as a novel drug carrier for the delivery of antiretroviral drug—Efavirenz " contained in the following link: