If 2 nanoparticles with sizes 150 nm and 500 nm are treated with same amount of a ligand eg,Folic acid, would the final actual tagged amount on the 2 particles differ? or would it be the same?
@Aya, yes it will differ as surface area is much more in 150 nm particle than 500 nm particle.
As stated above, the surface area will affect the take up. The surface areas differ by a factor of 5002 to 1502 with the smaller particles having the greater specific surface area.
Yes, it does.
You can imagine the surface are from this equation:
S=6/(density*d)
d: is the diameter it is inversely propotio al
density is the particles density
Dear @ Aya Ezzat ,
Please note that:
1- If you compare only two particles, as you stated in the question, then the larger particle has higher surface area and, hence, tagged higher amount of ligand.
2- If you compare two particle sizes per unit weight, as the experts assumed in the above answers, then the smaller particles have higher total surface area.
3- In the above notes, it is assumed that the two systems of particles have the same surface structure and features, moreover, the effect of the agglomeration/aggregation is NOT considered.
Yes, of course nano particle size is a matter in ligand desity. When the size is big then other then the surface area becomes larger than other. So it will affect the density.
Agnishwar Girigoswami SSA is surface to volume and D(3,2) = 6/SSA. Of course, larger particles possess a larger surface area but not on a per volume/mass basis. You are correct to point out this distinction.
- Badges
- Science topic
- Similar topics
- Chemistry
- Nanotechnology
- Nanostructured Materials
- Nanoparticles